Fig. 1.

miRNAs involved in osteogenic and chondrogenic differentiation of SSCs isolated from human bone marrow. Following routine total hip replacement, the femoral head is removed and bone marrow sample donated for isolation of SSCs. From the bone marrow sample, mononuclear cells are isolated by density centrifugation and the cell population enriched for SSCs by magnetic separation. MiRNAs involved in either chondrogenic or osteogenic differentiation are indicated by association with the relevant arrow. MiRNAs in red negatively regulate differentiation and in green positively regulate differentiation