Fig. 5.

Treatment effects on ARMS tumor xenograft growth. Nude mice bearing Rh41 human xenografts were treated for 28 days with either vehicle (control) or ceritinib (25 or 50 mg/kg). a Relative tumor volume of control and treated mice. Values are presented as mean ± SD. b Graphic representation of relative tumor growth for the control and treated (25 or 50 mg/kg) groups. Quantitative immunohistochemical analysis of caspase-3 levels for all three treatment groups. Values are presented as mean ± SD, *p < 0.05, **p < 0.01