TABLE 2.
MIC/MEC distributions of the antifungal drugs tested in the study for the Aspergillus species clinical isolates
| No. or WTa | Lab no. | Date received (day/mo/yr) | Species | MIC/MEC (mg/liter) |
Cyp51A changesb | Fks1 changesa | ST | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ISA | ITR | POS | VOR | CSF | MCF | AMB | TERB | |||||||
| 1 | 22432 | 2/9/2010 | A. fumigatus | 0.25 | 0.25 | 0.12 | 0.25 | 0.12 | 0.03 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 2 | 23525 | 5/4/2010 | A. fumigatus | 0.25 | 0.25 | 0.12 | 0.12 | 0.12 | 0.03 | 2 | 0.5 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 3 | 24053A | 6/15/2010 | A. fumigatus | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | S53G | 12 |
| 4 | 24053B | 6/15/2010 | A. fumigatus | 0.5 | 0.25 | 0.25 | 1 | 2 | 2 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | S53G and F675S | 9 |
| 5 | 24555 | 7/28/2010 | A. fumigatus | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 0.5 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 6 | 29576A | 7/27/2011 | A. flavus | 0.25 | 0.5 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 0.06 | WTc | ND | ND |
| 7 | 29576B | 7/27/2011 | A. fumigatus | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 0.5 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 8 | 30906 | 10/25/2011 | A. fumigatus | 0.25 | 0.5 | 0.25 | 0.12 | 0.12 | 0.03 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | ND | 12 |
| 9 | 33460 | 4/10/2012 | A. fumigatus | 0.25 | 0.5 | 0.25 | 0.12 | 0.12 | 0.03 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 10 | 45755 | 12/30/2013 | A. fumigatus | 2 | 1 | 1 | 0.5 | 0.12 | 0.03 | 2 | 1 | Y46F, V172 M, T248N, E255D, K427E | ND | 12 |
| 11 | 53619 | 1/28/2015 | A. fumigatus | 0.25 | 0.5 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 0.5 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| 12 | 62194 | 12/24/2015 | A. fumigatus | 0.25 | 0.5 | 0.25 | 0.12 | 0.12 | 0.03 | 2 | 0.5 | Y46F, V172 M, T248N, E255D, K427E | ND | 9 |
| ATCC 13073 | A. fumigatus | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 1 | ND | S53G | ND | ||
| R21 | A. fumigatus | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.03 | 2 | 2 | ND | S53G | ND | ||
| Af293 | A. fumigatus | 0.12 | 0.12 | 0.12 | 0.12 | 0.06 | 0.03 | 1 | 0.5 | ND | WT | ND | ||
a
The three WT strains (ATCC 13073, R21, and Af293) were included for comparison purposes.
b
Reference strain used was Af293. ND, not determined.
c
Reference strain used was A. flavus NRRL3357.