TABLE 3.

PK parameters for simeprevir in panel 1^a

Parameter	Value for patients receiving the following:
	SMV, 150 mg, + SOF, 400 mg QD (reference, day 14)	SMV, 150 mg QD, + LDV-SOF, 90/400 mg QD (test, day 28)
No.	20b	20c
Ctrough, ng/ml	1,548 (138.5)	5,250 (76.4)
Cmin, ng/ml	936 (156.7)	4,394 (62.4)
Cmax, ng/ml	4,193 (94.0)	9,951 (56.8)
Tmax, h	6.00 (4.00–12.00)	6.00 (0.47–10.00)
AUCτ, ng · h/ml	54,735 (115.3)	166,157 (65.3)
Css,avg, ng/ml	2,284 (115.2)	6,914 (65.4)

^aAll values are geometric means (coefficient of variations, expressed as percents) except in the case of T_max, for which values are medians (ranges).

^bn = 19 for C_trough due to a missing PK sample at trough.

^cn = 19 for C_max, T_max, AUC_τ, and C_ss,avg due to a missing PK sample around the time of expected C_max.