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MPC-1 inhibits class C β-lactamase through slow acylation and defective deacylation. (a) Determination of IC50 of MPC-1 against class C β-lactamase P99 with nitrocefin assay. (b) Time-dependent mass spectrum profile of P99–MPC-1 acyl adduct formation when the MPC-1 concentration is 10 μM. ka is derived by fitting the ratio of [EI*]/[E + EI*] versus time to equation 2.
