Table 3.
Comparison of hydrocephalus CSF samples grouped according to the patients' symptoms.
| Headache | |||
| Yes | no | p | |
| n | 9 | 56 | |
| Age (years) | 1.8 (1.0 – 7.6) | 0.3 (0 – 14.3) | < 0.001 |
| Protein (mg/dL) | 388 (93–833) | 211 (14 – 1284) | > 0.1 |
| NGF (pg/mL) | 498 (163–1815) | 141 (< 1 – 2025) | 0.022 |
| NGF/protein ratio | 1.20 (0.78 – 3.32) | 0.82 (0.04 – 59.09) | > 0.1 |
| Low NGF (< 10 pg/mL) | 0 (0 %) | 15 (27 %) | > 0.1 |
| Undetectable NT-3 | 1 /4 | 16 /27 | > 0.1 |
| Acute papilledema | |||
| Yes | No | p | |
| n | 4 | 61 | |
| Age (years) | 3.3 (1.8 – 5.0) | 0.3 (0 – 14.3) | 0.014 |
| Protein (mg/dL) | 273 (98 – 638) | 248 (14 – 1284) | > 0.1 |
| NGF (pg/mL) | 432 (225 – 548) | 200 (< 1 – 2025) | > 0.1 |
| NGF/protein ratio | 1.78 (0.78 – 3.32) | 1.0 (0.04 – 59.09) | > 0.1 |
| Low NGF (< 10 pg/mL) | 0 (0 %) | 9 (15 %) | > 0.1 |
| Undetectable NT-3 | 0 /1 | 7 /20 | > 0.1 |
| Decreased consciousness | |||
| Yes | No | p | |
| n | 16 | 49 | |
| Age (years) | 1.8 (0.1 – 14.3) | 0.2 (0 – 7.6) | < 0.001 |
| Protein (mg/dL) | 251 (47 – 822) | 211 (14 – 1284) | > 0.1 |
| NGF (pg/mL) | 280 (< 1 – 1815) | 200 (< 1 – 2025) | > 0.1 |
| NGF/protein ratio | 2.30 (0.05 – 9.43) | 0.63 (0.04 – 59.09) | > 0.1 |
| Low NGF (< 10 pg/mL) | 1 (6 %) | 8 (16 %) | > 0.1 |
| Undetectable NT-3 | 3 /6 | 14 /25 | > 0.1 |
| Bulging fontanel | |||
| Yes | No | p | |
| n | 44 | 21 | |
| Age (years) | 0.2 (0 – 5.10) | 3.3 (0 – 14.3) | < 0.001 |
| Protein (mg/dL) | 251 (36 – 1284) | 210 (14–853) | > 0.1 |
| NGF (pg/mL) | 122 (< 1 – 2025) | 365 (25 – 1815) | 0.054 |
| NGF/protein ratio | 0.59 (0.04 – 14.82) | 2.30 (0.09 – 59.09) | > 0.1 |
| Low NGF (< 10 pg/mL) | 9 (20 %) | 0 (0 %) | 0.048 |
| Undetectable NT-3 | 13 /21 | 4 /10 | > 0.1 |
| Vomiting | |||
| Yes | No | p | |
| n | 35 | 30 | |
| Age (years) | 0.5 (0 – 11.2) | 0.2 (0 – 14.3) | 0.083 |
| Protein (mg/dL) | 334 (47 – 853) | 187 (14 – 1284) | > 0.1 |
| NGF (pg/mL) | 129 (< 1 – 2025) | 331 (< 1 – 1876) | > 0.1 |
| NGF/protein ratio | 0.61 (0.05 – 7..47) | 1.72 (0.04 – 59.09) | 0.028 |
| Low NGF (< 10 pg/mL) | 9 (13 %) | 4 (14 %) | > 0.1 |
| Undetectable NT-3 | 5 /12 | 12 /19 | > 0.1 |
| Widening skull sutures | |||
| Yes | No | p | |
| n | 42 | 23 | |
| Age (years) | 0.1 (0 – 5.1) | 2.4 (0.1 – 14.3) | < 0.001 |
| Protein (mg/dL) | 248 (36 – 1284) | 224 (14 – 853) | > 0.1 |
| NGF (pg/mL) | 102 (< 1 – 2025) | 365 (< 1 – 1815) | 0.052 |
| NGF/protein ratio | 0.57 (0.04 – 14.82) | 2.45 (< 1 – 59.09) | 0.028 |
| Low NGF (< 10 pg/mL) | 7 (17 %) | 2 (9 %) | > 0.1 |
| Undetectable NT-3 | 13 /20 | 4 /11 | > 0.1 |
| Increasing head circumference | |||
| Yes | No | p | |
| n | 47 | 18 | |
| Age (years) | 0.3 (0 – 7.6) | 2.35 (0 – 14.3) | 0.028 |
| Protein (mg/dL) | 271 (36 – 1284) | 139 (14 – 680) | 0.025 |
| NGF (pg/mL) | 238 (< 1 – 2025) | 180 (< 1 – 1772) | > 0.1 |
| NGF/protein ratio | 0.78 (0.04 – 14.82) | 2.65 (0.19 – 59.09) | 0.034 |
| Low NGF (< 10 pg/mL) | 6 (13 %) | 3 (17 %) | > 0.1 |
| Undetectable NT-3 | 13 /21 | 4 /10 | > 0.1 |