TABLE 2.
Inhibition constants for inhibition of β-lactamases by sulbactama
| Enzymeb | kinact/Ki (M−1 s−1) | koff (s−1) | Ki (μM) |
|---|---|---|---|
| Class A | |||
| CTX-M-15 | 0.018 | ||
| KPC-2 | 26 | 0.0007 | |
| SHV-5 | 129,000 | 0.002 | |
| TEM-1 | 5,300 | 0.001 | |
| Class B | |||
| VIM-1 | 2,400 | ||
| Class C | |||
| ADC-7 | 44 | 0 | |
| AmpC | 32 | 0.00003 | |
| P99 | 19 | 0 | |
| Class D | |||
| OXA-10 | 22 | 0 | |
| OXA-23 | 130 | ||
| OXA-24 | 0.4 | 0.0008 | |
| OXA-48 | 4 | 0.0002 |
a
Examples of the global fit of the data to the kinetic model are shown in Fig. S3 for SHV-5, CTX-M-15, and P99.
b
AmpC, Pseudomonas aeruginosa class C chromosomal AmpC; P99, Enterobacter cloacae class C chromosomal β-lactamase; ADC-7, Acinetobacter baumannii class C chromosomal β-lactamase.