TABLE 3.
Turnover numbers for sulbactam with β-lactamases, measured after 1 h or 5 h of incubationa
| Enzymeb | Turnover number |
|
|---|---|---|
| 1–2 h | 5–6 h | |
| Class A | ||
| CTX-M-15 | 70 | 280 |
| KPC-2 | 2,300 | 10,000 |
| SHV-5 | 440 | 660 |
| TEM-1 | 14,000 | 9,400 |
| Class C | ||
| ADC-7 | 9 | 9 |
| AmpC | 16 | 18 |
| P99 | 30 | 33 |
| Class D | ||
| OXA-10 | 6,400 | 2,900 |
| OXA-23 | 18,000 | 23,000 |
| OXA-24 | ≫34,000 | ≫34,000 |
| OXA-48 | 43,000 | 42,000 |
a
Experimental data are shown in Fig. S3.
b
AmpC, Pseudomonas aeruginosa class C chromosomal AmpC; P99, Enterobacter cloacae class C chromosomal β-lactamase; ADC-7, Acinetobacter baumannii class C chromosomal β-lactamase.