FIG 2.

Prediction-corrected visual predictive check (pcVPC) plots of the prophylaxis study data and the PPRU study model with fixed parameter values (a), the merged data set and the PPRU study model with fixed parameter values (b), the PPRU study data set and the prophylaxis study model with fixed parameter values (c), and the merged data set and the prophylaxis study model with fixed parameter values (d). All pcVPC plots are based on time after the last dose, and the data on the y axis are log transformed. Dashed lines, the 5%-50%-95% interval for the observed data; gray shaded regions, the 90% prediction interval for the predicted concentrations.