TABLE 2.

Comparison of quantitative measures of bias and precision for the PPRU study and prophylaxis study models

Model and data set	PEc (μg/ml)	MPEd (%)	MAPEe (%)
PPRU study modela
PPRU study	0.132 (−4.76, 8.39)	15.3 (−51.1, 153)	35.7
Prophylaxis study	0.429 (−3.31, 11.2)	41.9 (−43.3, 302)	57.6
Merged	0.338 (−6.10, 9.86)	33.7 (−64.4, 296)	59.2
Prophylaxis study modelb
Prophylaxis study	0.339 (−3.61, 3.10)	12.2 (−47.4, 141)	31.8
PPRU study	2.45 (−4.05, 65.4)	188 (−40.3, 848)	195
Merged	−0.245 (−5.15, 9.66)	20.1 (−66.4, 250)	53.9

^aPatients in the PPRU study received fluconazole at 3 to 12 mg/kg i.v., given every 1 to 3 days.

^bPatients in the prophylaxis study received fluconazole at 6 mg/kg twice weekly (Tuesdays and Fridays) i.v. or p.o.

^cPE, prediction error, which is presented as the median (2.5th percentile, 97.5th percentile).

^dMPE, mean prediction error, which is presented as the mean (2.5th percentile, 97.5th percentile).

^eMAPE, mean absolute prediction error.