FIG 2.

Genetic determinants of intrinsic antibiotic resistance are shared between different antibiotics. (A) Overlap between CGI profiles. The overlap matrix indicates the number of genes shared between pairs of antibiotic sensitivity profiles (numbers not in parentheses). The degree of overlap is represented in the form of the Jaccard index (numbers in parentheses), i.e., the proportion of sensitivity genes shared between the two libraries over the total number of genes from both libraries [(A ∩ B)/(A ∪ B), where A and B are different sets of sensitive mutants]. (B) Venn diagram of antibiotic-sensitive mutants. Sets of significantly sensitive mutants (negative TnSeq-FC, q < 0.05) for each antibiotic are represented by the colored regions, with the number of overlapping genes in their respective zones being indicated. RIF, rifampin; INH, isoniazid; EMB, ethambutol; MERO or MER, meropenem; VAN, vancomycin.