TABLE 4.
Values of pharmacokinetic parameters for isavuconazole and voriconazole in plasma and brain following a single oral administration in ratsa
| Compound and matrix | t1/2 (h) | Tmax (h) | Cmax (μg/ml) | AUClast (μg · h/ml) | tlast (h) | AUCinf (μg · h/ml) |
|---|---|---|---|---|---|---|
| Isavuconazole | ||||||
| Brain | 3.7 | 3.0 | 6.95 | 53.7 | 24 | 54.3 |
| Plasma | 3.8 | 3.0 | 3.67 | 30.3 | 24 | 30.7 |
| Voriconazole | ||||||
| Brain | ND | 3.0 | 48.07 | 321.5 | 8 | ND |
| Plasma | 2.1 | 1.0 | 21.97 | 304.5 | 24 | 304.7 |
a
AUCinf, area under the concentration-time curve from time zero to infinity; AUClast, area under the concentration-time curve from time zero to the last measurable time point; Cmax, maximum concentration observed; ND, not determined; t1/2, half-life; tlast, last measurable time point; Tmax, time of maximum concentration observed.