TABLE 1.
MICs and FICI results with combinations of FK506 with triazoles against planktonic E. dermatitidis
| Strain | MIC (μg/ml) for: |
||||||
|---|---|---|---|---|---|---|---|
| Agent alone |
Combinationa |
||||||
| FK506 | ITC | VRC | POS | FK506/ITC | FK506/VRC | FK506/POS | |
| BMU00028 | >16 | 1 | 0.25 | 0.5 | 2/0.03 (S) | 4/0.03 (S) | 2/0.03 (S) |
| BMU00029 | >16 | 1 | 0.5 | 0.5 | 1/0.03 (S) | 1/0.5 (I) | 2/0.015 (S) |
| BMU00030 | >16 | 0.5 | 0.25 | 0.5 | 1/0.25 (I) | 1/0.06 (S) | 2/0.015 (S) |
| BMU00031 | >16 | 1 | 0.5 | 0.5 | 1/0.06 (S) | 2/0.125 (S) | 2/0.03 (S) |
| BMU00034 | >16 | 0.5 | 0.5 | 0.5 | 1/0.06 (S) | 2/0.125 (S) | 1/0.03 (S) |
| BMU00035 | >16 | 1 | 0.5 | 0.5 | 1/0.25 (S) | 2/0.03 (S) | 2/0.015 (S) |
| BMU00037 | >16 | 1 | 0.5 | 1 | 2/0.5 (I) | 0.25/0.5 (I) | 1/0.015 (S) |
| BMU00038 | >16 | 0.5 | 0.25 | 0.25 | 4/0.25 (I) | 2/0.03 (S) | 2/0.015 (S) |
| BMU00039 | >16 | 0.5 | 0.25 | 0.5 | 2/0.125 (S) | 2/0.06 (S) | 2/0.015 (S) |
| BMU00040 | >16 | 1 | 0.5 | 1 | 2/0.125 (S) | 2/0.125 (S) | 1/0.03 (S) |
| BMU00041 | >16 | 1 | 0.25 | 0.5 | 2/0.06 (S) | 2/0.06 (S) | 1/0.03 (S) |
| 109140 | >16 | 0.5 | 0.5 | 1 | 1/0.125 (S) | 2/0.125 (S) | 1/0.03 (S) |
| 109145 | >16 | 0.5 | 0.25 | 1 | 2/0.25 (I) | 2/0.06 (S) | 1/0.03 (S) |
| 109148 | >16 | 1 | 0.25 | 0.5 | 1/0.125 (S) | 2/0.06 (S) | 2/0.03 (S) |
| 109149 | >16 | 1 | 0.5 | 0.5 | 1/0.06 (S) | 4/0.06 (S) | 2/0.03 (S) |
| 109152 | >16 | 0.5 | 0.25 | 0.5 | 2/0.25 (I) | 1/0.03 (S) | 1/0.015 (S) |
a
FICI results are shown in parentheses. S, synergy (FICI of ≤0.5); I, indifference (no interaction [FICI of >0.5 to ≤4]).