TABLE 5.

Clinical predictors of inappropriate empirical antimicrobial therapy in adults with community-onset bacteremia

Variable	Analysis resulta
	Univariate		Multivariateb
	OR (95% CI)	P value	AOR (95% CI)	P value
Nursing home residents	2.33 (1.60–3.40)	<0.001	1.66 (1.01–2.12)	0.049
Antimicrobial use within 4 wk before ED arrival	2.28 (1.80–2.89)	<0.001	2.53 (1.60–4.02)	<0.001
Polymicrobial bacteremia	2.55 (1.91–3.41)	<0.001	1.53 (1.10–2.12)	0.01
Causative microorganism
ESBL-producing EKP	14.00 (8.39–23.35)	<0.001	11.83 (6.68–20.96)	<0.001
Methicillin-resistant S. aureus	10.90 (7.27–16.32)	<0.001	7.88 (5.12–12.15)	<0.001
Levofloxacin nonsusceptible EKP	7.30 (5.39–9.89)	<0.001	4.21 (3.04–5.85)	<0.001
Pseudomonas species	3.71 (2.40–5.71)	<0.001	NS	NS
Bacteremia source
Vascular-line infection	2.56 (1.64–4.00)	<0.001	NS	NS
Liver abscess	0.17 (0.05–0.54)	0.001	NS	NS
Comorbidities
Neurological disease	1.85 (1.47–2.33)	<0.001	1.38 (1.03–1.86)	0.03
Chronic kidney disease	1.41 (1.09–1.82)	0.008	NS	NS
Diabetes mellitus	1.24 (1.00–1.54)	0.046	NS	NS

^aCalculated by chi-square or multivariate regression tests. Boldface indicates statistical significance, i.e., a P value of <0.05.

^bNS, no significance (after processing the backward multivariate regression).