TABLE 6.

Risk factors of 28-day mortality in adults with community-onset bacteremia

Variable at bacteremia onset	Analysis resulta
	Univariate		Multivariateb
	OR (95% CI)	P value	AOR (95% CI)	P value
Gender, male	1.52 (1.21–1.94)	<0.001	NS	NS
Nursing home residents	2.87 (1.95–4.23)	<0.001
Ultimately or rapidly fatal comorbidity (McCabe classification)	3.50 (2.76–4.45)	<0.001	2.13 (1.52–2.98)	<0.001
Polymicrobial bacteremia	2.30 (1.68–3.16)	<0.001
Inappropriate EAT	2.12 (1.63–2.75)	<0.001	2.60 (1.88–3.60)	<0.001
Pitt bacteremia score of ≥4	11.82 (9.14–15.28)	<0.001	10.69 (8.00–14.28)	<0.001
Causative microorganism
ESBL-producing EKP	3.25 (2.02–5.27)	<0.001
Pseudomonas species	2.88 (1.81–4.57)	<0.001	NS	NS
Klebsiella pneumoniae	1.83 (1.38–2.44)	<0.001	NS	NS
Escherichia coli	0.45 (0.35–0.58)	<0.001	NS	NS
Bacteremia source
Pneumonia	4.74 (3.63–6.18)	<0.001	2.00 (1.41–2.82)	<0.001
Urinary tract infection	0.24 (0.17–0.34)	<0.001	0.37 (0.25–0.55)	<0.001
Biliary tract infection	0.57 (0.35–0.91)	0.02	NS	NS
Liver abscess	0.31 (0.11–0.85)	0.02	NS	NS
Major comorbidities
Malignancy	2.67 (2.11–3.38)	<0.001	1.95 (1.34–2.83)	0.001
Neurological disease	1.42 (1.09–1.84)	0.008
Liver cirrhosis	2.00 (1.49–2.70)	<0.001	1.86 (1.36–2.26)	<0.001
Hypertension	0.74 (0.59–0.94)	0.01	NS	NS

^aCalculated by chi-square or multivariate regression tests.

^bNS, no significance (after processing the backward multivariate regression).