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. 2017 Nov 22;61(12):e01575-17. doi: 10.1128/AAC.01575-17

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Copyright © 2017 Nakatani et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Determination of DCS IC₅₀ for wild-type (wt) Alr_Mtb and the M319T, Y364D, and R373L mutants. The activity was normalized against a control with no DCS present in the assay mixture. The activity assay at each concentration was performed in triplicate, resulting in the error bars, which represent the 95% confidence interval. A variable slope model was fitted to determine the IC₅₀s, which were 26.4 ± 1.7, 1,328.0 ± 340.0, and 712.0 ± 138.5 μM for the wild-type, Y364D, and R373L enzymes, respectively. The inhibition of M319T was too weak to allow for IC₅₀ determination.