TABLE 3.
Disease severity scores and patient size descriptors correlated with micafungin exposure (AUC)
| Parametera | Median value (IQR) | Spearman r | P value |
|---|---|---|---|
| APACHE II score | 15 (13–19) | 0.405 | 0.085 |
| APACHE IV score | 83 (51–107) | 0.339 | 0.156 |
| LODS score | 5 (4–7) | 0.339 | 0.156 |
| MODS | 4 (2–6) | 0.542 | 0.017 |
| MPMII (%) | 55.0 (30.0–66.0) | −0.035 | 0.886 |
| ODIN score | 3 (3–4) | 0.301 | 0.211 |
| SAPS III | 55 (38–66) | 0.421 | 0.072 |
| SOFA score | 4 (3–9) | 0.548 | 0.015 |
| Body wt (kg) | 85 (65–98) | −0.488 | 0.034 |
| BMI (kg m−2) | 27.5 (22.7–33.9) | −0.321 | 0.180 |
| BSA (m2) | 2.02 (1.81–2.20) | −0.545 | 0.016 |
| LBM (kg) | 64.1 (50.6–75.9) | −0.485 | 0.035 |
| FFM (kg) | 58.1 (45.3–69.5) | −0.546 | 0.016 |
a
APACHE II, acute physiology and chronic health evaluation II; LODS, logistic organ dysfunction system; MODS, multiple-organ dysfunction score; MPMII, mortality prediction model II; ODIN, organ dysfunctions and/or infection; SAPS III, simplified acute physiology score III; SOFA, sequential organ failure assessment; BMI, body mass index; BSA, body surface area; LBM, lean body mass; FFM, fat-free mass.