FIG 3.

Dose-dependent potentiation effect of fumarate on TOB sensitivity in P. aeruginosa COPD isolates. Early and late patient isolates with respect to disease progression were obtained from A. Oliver (6). Plots of percent survival versus TOB concentration in the PSP assay are shown for an early isolate from a patient (5072829) (A) and for a late isolate from the same patient (919193) (B). Strains 5072829 and 919193 are genetically identical (as determined by pulsed-field gel electrophoresis) and have a TOB MIC of 0.25 μg/ml. Values of percent survival depict the mean ± SD (n = 2).