TABLE 1.
Most TOB-susceptible P. aeruginosa CF clinical isolates are potentiated by fumarate
| Strain | Mucoid | MIC (μg/ml)a | Potentiation (log10) |
|---|---|---|---|
| 10028 | Yes | 1 | 5 |
| 10048 | Yes | 0.25 | 4.5 |
| 10005 | Yes | 0.25 | 5 |
| 14003 | Yes | 0.5 | 6 |
| 10140 | Yes | 0.5 | 5 |
| 10063-Sb | Yes | 0.5 | 4.5 |
| 10063-Lb | No | 0.25 | 4.5 |
| 10013 | No | 0.25 | 4 |
| 10019 | No | 0.25 | 5 |
| 10002 | No | 0.25 | 4 |
| 10001 | No | 0.25 | 5 |
| 10008 | No | 0.25 | 4.5 |
| 10004 | No | 0.25 | 4.5 |
| 10045 | No | 0.25 | 3 |
| 10054 | No | 0.5 | 5 |
| 14001 | No | 0.5 | 3.5 |
| 10015 | No | 4 | 2 |
| 10077 | Yes | 0.25 | No |
| 10020 | No | 0.5 | No |
a
MICs are for TOB alone in an in vitro assay in MHB under standard CLSI conditions, as described in Materials and Methods under “Characterization of bacterial strains.” The addition of fumarate does not affect the values (see Table S1).
b
S, small colonies; L, large colonies.