TABLE 2 .

List of A. aegypti differentially expressed genes with more than 10-fold change specific to each time point post-ZIKV infection

Name	Gene identifier	Description	Fold changea
			Day 2	Day 7	Day 14
AAEL011539	5574950	Metalloproteinase, putative	56.2	−1.1	3.31
AAEL013298	5577578	Serine protease, putative	22.08	1.86	4.74
AAEL007601	5569396	Trypsin 5G1-like	18.98	3.46	3.06
AAEL013707	5578506	Trypsin 5G1-like	10.07	6.24	1.81
AAEL011260	5574623	Protein D3	−10.95	3.1	−0.18
AAEL011954	5575620	Elongation of very-long-chain fatty acids protein 7	−11.96	1.56	1.14
AAEL014312	5564093	Cubilin homolog	−12.1	8.42	1.87
AAEL010965	5574152	Cubilin homolog	−12.49	1.4	−1.61
AAEL010139	5572918	Putative defense protein 1	−14.85	34.42	0.9
AAEL003094	5577074	Glycoprotein, putative	−16.59	6.43	−1.29
AAEL011491	5574891	General odorant binding protein 67	−17.05	−2.93	0.46
AAEL001487	5570904	General odorant binding protein 45-like	−17.49		2.66
AAEL004947	5565723	Elongation of very-long-chain fatty acids protein 4	−18.74	−2.25	5.11E−3
AAEL005090	5565985	Cysteine-rich venom protein, putative	−18.75	3.74
AAEL010875	5574034	General odorant binding protein 45-like	−20.22
AAEL007096	5568731	Major royal jelly protein 3	−21.97	1.01	0.67
AAEL010848	5574004	Major royal jelly protein 5	−23.73	1.45	−0.67
AAEL010872	5574030	General odorant binding protein 45-like	−27.81	−8.89	0.38
AAEL011808	5575404	Glucose dehydrogenase (flavin adenine dinucleotide, quinone)	−29.51	−1.01	3.95E−3
AAEL006398	5567938	OBP32, odorant binding protein OBP32	−31.43	1.71
AAEL006393	5567943	OBP28, odorant binding protein OBP28	−35.93	−6.24
AAEL005925	5567269	Geranylgeranyl pyrophosphate synthase	−38.51	3.74	2.96E−3
AAEL006396	5567937	OBP31, odorant binding protein OBP31	−56.46	−3.6	−1.31
AAEL003511	5578352	General odorant binding protein 45-like	−59.39	−1.75	0.79
AAEL015262	5566792	Phosphatidylethanolamine-binding protein, putative	−59.59	1.4	0.56
AAEL000796	5566894	General odorant binding protein 45-like	−302.47	3.74	2.66
AAEL015052	5566038	Steroid receptor RNA activator 1	−358.45	3.11	7.73
AAEL000827	5566899	General odorant binding protein 45-like	−362.89	−1.75
AAEL000846	5566895	General odorant binding protein 45-like	−397.26	2.42	0.51
AAEL000833	5566896	General odorant binding protein 45-like	−739.97	2.42	1.27
AAEL000835	5566905	General odorant binding protein 45-like	−811.93		−0.78
AAEL000837	5566897	General odorant binding protein 45-like	−883.73	−1.01	2.67
AAEL000701	5565919	39S ribosomal protein L4, mitochondrial	1.25	438.21
AAEL015019	5565969	Protein artichoke	−1.43	42.54	1.31
DEFD	5579095	Defensin A-like	−8.11	31.28	−4.25
AAEL014386	5564283	Serine protease Easter	−2.06	30.31	2.23
DEFA_AEDAE	5579099	Defensin A	−7.35	21.99	−4.45
AAEL015430	5579444	Serine protease, putative	−1.19	21.79	−1.05
AAEL015639	5579270	Transferrin	−3.55	19.09	−1.67
AAEL014005	5579131	Clip-domain serine protease, putative	−2.03	17.69	1.47
CTLMA15	5563672	C-type lectin, 37 Da	−1.1	16.19	3.91
TRY5_AEDAE	5578510	Trypsin 5G1	−1.15	15.52	2.13
DEFC_AEDAE	5579094	Defensin C	−8.23	14.5	−5.59
AAEL013640	5578322	Lung carbonyl reductase	3.51	13.7	1.49
AAEL010429	5573346	Protein G12	5.92	13.51	25.07
AAEL002726	5575756	37-kDa salivary gland allergen Aed a 2-like	1.09	12.19	1.63
AAEL015458	5579417	Transferrin	−9.02	11.93	−1.19
AAEL013542	5578161	Elongation of very-long-chain fatty acids	−1.65	11.85	2.91
AAEL002672	5575549	Matrix metalloproteinase-19	−1.25	11.49	1.36
AAEL013990	5579047	Hexamerin-1.1	−1.16	10.97	1.96
AAEL005787	5567041	Serine protease Easter	−1.05	10.3	1.72
AAEL015628	5579281	Glycine dehydrogenase	2.92	10.07	1.84
AAEL004134	5564162	Lupus la ribonucleoprotein	2.24	−69.95	−2.86
AAEL003946	5563782	28S ribosomal protein S33, mitochondrial	−2.19	−101.56	1.57
AAEL009497	5572080	Probable phosphomannomutase	−1.25	−676.56	−3.51
AAEL015052	5566038	Steroid receptor RNA activator 1	−358.45	3.11	212.47
AAEL010429	5573346	Protein G12	5.92	13.51	25.07
AAEL009435	5571953	Adhesion-regulating molecule 1	−1.34	−1.21	13.51
AAEL002613	5575308	Peritrophin-48	3.23	−3.98	11.35
ATT	5578028	Attacin-B	4.4	−1.42	−10.49
AAEL007040	5568687	Protein lozenge, transcript variant X3	−1.83	45.7	−12.57
AAEL011550	5574942	Seminal metalloprotease 1	−1.93	1.71	−22.18
CUSOD3_a	5573744	Superoxide dismutase (Cu-Zn)	1.03	1.18	−39.11

^aValues in bold are fold changes greater than 10 specific to each time point.