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. 2017 Nov 22;37(47):11323–11334. doi: 10.1523/JNEUROSCI.2113-17.2017

Figure 1.

Figure 1.

Sensory neuron-specific deletion of αII spectrin. a, Teased dorsal roots of P14 Sptan1f/f, CNP-cre;Sptan1f/f, Avil-cre; Sptan1f/f, and CNP-cre;Avil-cre;Sptan1f/f mice immunostained with antibodies against αII spectrin (green), βII spectrin (red), and neurofilament-M (blue). Scale bar, 20 μm. b, Avil-cre; Sptan1f/f mice show a hind-limb clasping reflex. c, Footprint assay for 1-month-old Sptan1f/f and Avil-cre; Sptan1f/f mice. d, Wirehang test performed on 1-month-old mice. Sptan1f/f, N = 16; Avil-cre; Sptan1f/f, N = 12. Data are mean ± SEM. ***p = 2.808E-18, t(26) = 21.90. e, Tail immersion test performed on 1-month-old mice. Sptan1f/f: N = 9; Avil-cre; Sptan1f/f: N = 5. Data are mean ± SEM. f, Representative CAPs recorded from 1-month-old Sptan1f/f (black) and Avil-cre; Sptan1f/f (red) dorsal roots. g, Conduction velocities recorded from dorsal roots of 1-month-old mice. Sptan1f/f, N = 3 mice, 14 dorsal roots; Avil-cre; Sptan1f/f: N = 3 mice, 15 dorsal roots. Data are mean ± SEM. ***p = 0.0001, t(4) = 15.33.