Figure 3.

Physical characteristics of sham and mice treated with monocrotaline fed either normal chow (MCT) or EMBL ID#704946 compound (MCT + 704946). Data confirmed that MCT treatment induced cardiac cachexia independent of the chow administrated, as demonstrated by an impaired weight gain (A), increased pulmonary congestion (B), increased heart weight (C), and right ventricular (RV) hypertrophy (D), the latter visualized by representative haematoxylin and eosin‐stained sections (E). Data are presented as mean ± SEM, with n = 20 (sham), n = 27 (MCT), and n = 27 (MCT + 704946) per group. *P < 0.01 vs. sham.