Table 3.
Overall and recurrence-free survival according to patient characteristics and treatment variables
| Characteristic | 5-year overall survival (p-value) | 5-year recurrence-free survival |
|---|---|---|
| Sex | ||
| Male | 51.4% (0.539) | 56.7% (0.826) |
| Female | 50% | 75% |
| Age | ||
| < 40 years | 100% (0.136) | 100% (0.19) |
| ≧ 40 years | 49.1% | 56.9% |
| Smoking | ||
| Yes | 51.5% (0.536) | 57.2% (0.91) |
| No | 50% | 66.7% |
| Alcohol | ||
| Yes | 55.5% (0.311) | 57.6% (0.575) |
| No | 35.7% | 72.7% |
| Betel quid | ||
| Yes | 42.2% (0.068) | 50.8% (0.154) |
| No | 71.1% | 75.9% |
| Anemia | ||
| Yes | 29.2% (0.002)* | 54% (0.106) |
| No | 60.2% | 61% |
| Differentiation | ||
| Poor | 40% (0.752) | 30% (0.03)* |
| Well or moderate | 53.1% | 64% |
| pT stage | ||
| pT4 | 52.9% (0.978) | 64% (0.461) |
| pT1–3 | 48% | 50% |
| pN stage | ||
| N1 | 55.3% (0.481) | 62.7% (0.34) |
| N0 | 48.4% | 53.8% |
| Surgical margin | ||
| ≤ 4 mm | 48.2% (0.791) | 59.8% (0.587) |
| > 4 mm | 56% | 57.6% |
| Skin invasion | ||
| Yes | 59.3% (0.485) | 64.6% (0.428) |
| No | 48.9% | 57.1% |
| Bone invasion | ||
| Yes | 46.4% (0.44) | 55.4% (0.396) |
| No | 55% | 61.7% |
| Perineural invasion | ||
| Yes | 51.2% (0.953) | 58.8% (0.723) |
| No | 50.2% | 59.2% |
| Vascular invasion | ||
| Yes | 60% (0.444) | 60% (0.785) |
| No | 48.8% | 57% |
| Lymphatic invasion | ||
| Yes | 50% (0.948) | 50% (0.752) |
| No | 51.2% | 59.1% |
| Invasion depth | ||
| ≥ 11 mm | 52.1% (0.432) | 69.2% (0.177) |
| < 11 mm | 42.9% | 57.1% |
| RT technique | ||
| Other | 47.2% (0.623) | 51.7% (0.489) |
| IMRT | 56.1% | 78.3% |
| RT duration | ||
| > 8 weeks | 28.6% (0.07) | 28.6% (0.063) |
| ≤ 8 weeks | 53.7% | 62.3% |
| Time between OP & RT | ||
| > 6 weeks | 42% (0.192) | 48.2% (0.38) |
| ≤ 6 weeks | 57% | 65.5% |
| RT Dose | ||
| < 6600 cGy | 39.2% (0.065) | 50.8% (0.191) |
| 6600 cGy | 73.9% | 73.7% |
| Concurrent chemotherapy | ||
| No | 35.3% (0.018)* | 426% (0.009)* |
| Yes | 67.2% | 75.4% |
*Statistically significant in the multivariate analysis, p < 0.05
Abbreviations: RT radiotherapy, IMRT intensity-modulated radiotherapy, OP operation