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. 2017 Nov 9;2017:5301312. doi: 10.1155/2017/5301312

Figure 2.

Figure 2

The expressions of S1PL, SphK1, and SphK2 mRNA in lung tissues. Rats were divided into five groups: groups SM, IR, F3, F5, and F10. The rats in group SM received sham operation and bilateral limb IR (ischemia 3 h/reperfusion 3 h) in group IR. The rats in groups F3, F5, and F10 were treated with FTY720 3 mg/kg/d, 5 mg/kg/d, and 10 mg/kg/d, respectively, for 7 consecutive days before limb IR. Upon 3 h reperfusion, the expressions of S1PL, SphK1, and SphK2 mRNA were measured. S1PL: S1P lyase; SphK1: sphingosine kinase-1; SphK2: sphingosine kinase-2. ∗p < 0.05 versus group SM; #p < 0.05 versus group IR.