Table 2.
Presenting clinical and laboratory features
| Presenting features | Patients (N = 27) | |
|---|---|---|
| Symptoms: | ||
| Constitutional: | Malaise | 13 (48) |
| Weight loss | 8 (30) | |
| Fever (> 38.0 C) | 5 (19) | |
| Lymphadenopathy | 3 (11) | |
| Cardiovascular: | Claudication of the extremities | 6 (22) |
| Neurological: | Headache | 9 (33) |
| Dizziness | 5 (19) | |
| Stroke/TIA | 3 (11) | |
| Syncope | 3 (11) | |
| Gastrointestinal: | Chronic nausea/vomiting | 5 (19) |
| Nonspecific abdominal pain | 4 (15) | |
| Pulmonary: | Shortness of breath | 4 (15) |
| Chest pain | 3 (11) | |
| Musculoskeletal: | Back pain | 5 (19) |
| Ocular: | Blurred vision/uveitis/retinal hemorrhage | 4 (15) |
| Findings on clinical exam: | ||
| Blood pressure discrepancy | 18 (67) | |
| Decreased or absent pulse | 16 (59) | |
| Arterial hypertension | 15 (56) | |
| Bruits over large arteries | 15 (56) | |
| Laboratory characteristics: | ||
| ESR, mm/h | 35 (17–74) | |
| CRP, mg/dL | 31.9 (5.3–67.6) | |
| Hemoglobin, g/L | 115 (96.5–125.5) | |
| White blood cells, × 10^9/L | 8.8 (6.9–12.4) | |
| Platelets, × 10^9/L | 366 (256–543) | |
| vWF antigen, IU/mL | 1.6 (1.1–2.0) | |
| Impaired renal function | 2 (7) | |
| ANA | 8/22 (36) | |
| ANCA | 2/18 (11) | |
Clinical features present in > 10% of the patients with childhood TAK are listed. Impaired renal function was defined as a creatinine increase of > 30% of the upper normal limit at diagnosis. Values are presented as numbers (%) or medians (IQR)
TIA transient ischemic attack, ESR erythrocyte sedimentation rate, CRP C-reactive protein, vWF antigen von Willebrand factor antigen. ANA antinuclear antibody, ANCA antineutrophil cytoplasmic antibody