Table 1.
Characteristics of included studies.
| Studies | Study groups with the numbers of included women | Age (yr) Mean ± SD Normal pregnant women |
Age (yr) Mean ± SD Control group |
Gestational age (wk)+ mean ± SD | EDI-OCT | Type of measurement | Measured areas | SFCT (um) Mean ± SD |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal pregnant women (n) |
Normal non-pregnant women (n) |
Women with Preeclampsia (n) |
Women after pregnancy (n) |
Normal pregnant women |
Control group | |||||||
| Liu et al. | 46 | 71 | Not applicable | Not applicable | 27.87 ± 3.65 | 28.43 ± 3.15 | 28–38 (30.20 ± 1.63) |
Heidelberg | Manually | SFCT, 1 mm and 3 mm nasally, temporally, superiorly, inferiorly |
344.13 ± 50.94 | 315.03 ± 60.57 |
|
| ||||||||||||
| Takahashi et al. | 25 | 27 | Not applicable | Not applicable | 30.4 ± 6.0 | 30.0 ± 6.3 | 27–38 (31.0 ± 3.2) |
Heidelberg | Manually | SFCT, 3 mm temporally; 3 mm nasally; 3 mm superiorly; 3 mm inferiorly |
275 ± 84 | 273 ± 92 |
|
| ||||||||||||
| Kara et al. | 100 | 100 | Not applicable | Not applicable | 28.6 ± 6.3 | 30.5 ± 6.2 | 15–38 (27.3 ± 6.6) |
Cirrus HD-OCT | Manually | SFCT | 371.1 ± 61.8 | 337.2 ± 62.4 |
|
| ||||||||||||
| Ulusoy et al. | 29 | 36 | Not applicable | 29 | 27.41 ± 5.48 | 28.00 ± 5.27 | 28–39 (31.97 ± 3.77) |
Heidelberg | Manually | SFCT | 387.97 ± 59.91 | 320.86 ± 59.18 |
|
| ||||||||||||
| Dadaci et al. | 27 | 25 | Not applicable | Not applicable | 28.9 ± 5.5 | 29.2 ± 7.0 | 6–8 (6.8 ± 0.8) 32–37 (35.1 ± 1.9) |
Cirrus HD-OCT | Manually | SFCT; three locations nasal and three locations temporal to the fovea at 500 um intervals |
I trimester OP 349.22 ± 82.11 μm III trimester OP 333.56 ± 76.61 μm I trimester OL 341.30 ± 85.22 μm III trimester OL 326.93 ± 75.84 μm |
OP-318.88–53.13 OL-310.60–51.09 |
|
| ||||||||||||
| Sayin et al. | 46 | 40 | 33 | Not applicable | 28.1 ± 6.2 | 30.2 ± 6.2 | 17–37 (28.0 ± 5.8) |
Cirrus-HD-OCT | Manually | SFCT | 368.6 ± 67.6 | 334.8 ± 59.9 |
|
| ||||||||||||
| Goktas et al. | 90: 30 - I trimester 30 - II trimester 30 – III trimester |
30 | Not applicable | Not applicable | 28.5 ± 6.4 26.6 ± 4.2 26.9 ± 6.2 |
29.4 ± 2 | 7.4 ± 2.6 19.2 ± 2.9 33.1 ± 2.8 |
Heidelberg | Manually | SFCT; 3 mm temporally; 3 mm nasally |
I trimester 362 ± 81 II trimester 395 ± 80 III trimester 368 ± 70 |
335 ± 86 |
|
| ||||||||||||
| Kim et al. | 14 | 21 | 7 | Not applicable | 31.43 ± 2.88 | 30.43 ± 4.15 | 32.14 ± 2.69 | Heidelberg | Manually | SFCT | 274.23 ± 29.30 | 264.95 ± 21.03 |
|
| ||||||||||||
| Rothwell et al. | 12 | 12 | Not applicable | Not applicable | 32.77 ± 2.08 | 32.92 ± 3.01 | 29–35 32.4 |
Heidelberg | Automatically | SFCT; + 9 subfields defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) | 319.58 ± 6.11 | 287.58 ± 43.44 |
|
| ||||||||||||
| Ataş et al. | 25 | 26 | 27 | Not applicable | 27.76 ± 5.21 | 29 ± 7.1 | 31.37 ± 4.9 | Heidelberg | Manually | SFCT | 387.2 ± 60.76 | 322.35 ± 63.89 |