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Schematic of anti-EGFR antibody cetuximab conjugated to lipid-encapsulated nonfouling SPIO nanoparticles. Maghemite nanoparticles were modified with maleimide through reaction with sulfo-SMCC; a thiolated antibody was prepared by treating cetuximab with iminothiolane. The maleimide-functionalized SPIO nanoparticles were mixed with the thiolated antibody solution to form antibody-conjugated SPIO nanoparticles. The lipid-coated surface of SPIO nanoparticles provides a nonfouling property
