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. 2017 Nov 22;19:256. doi: 10.1186/s13075-017-1462-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Last documented response for the tociizumab (TOC) cohort (a), combined IL-1 inhibitor (IL-1i) cohort (b), canakinumab cohort (c) and anakinra (ANA) cohort (d). The rate of patients with no active joints, no fever, Juvenile Disease Activity Score (JADAS)-remission, American College of Rheumatology (ACR)-defined inactive disease, ACR-remission is given, respectively, in the total cohort and for biologic-naive and pre-exposed patients. Differences in rates were calculated using the chi-square-test. Pearson’s p value is outlined if < 0.05. ETA, etanercept