Table 4.

Association between Dysnatremia and In-Hospital mortality. Comparison of the different regression models

Association Between Borderline Hyponatremia and Mortality
	OR (IC95%)	P	AIC
Classical Modela	1.98 (1.73–2.68)	<.001	8098.4
PheWAS Modelb	2.59 (2.28–2.94)	<.001	11,002
Final Modelc	1.57 (1.35–1.81)	<.001	7585.5
Association Between Borderline Hypernatremia and Mortality
	OR (IC95%)	P	AIC
Classical Modeld	3.72(1.53–8.45)	<.001	6077.9
PheWAS Modele	6.23(4.60–8.33)	<.001	8761.9
Final Modelf	3.47(2.43–4.90)	<.001	5920.8

Confounding Factors Retained in the different models:

^aClassical model: age, duration of hospital stay, number of ICD-10 codes, hospital admissions via the emergency department, ICU stay, dialysis, palliative care, Charlson Comorbidity Index

^bPheWAS model: A41, I20, I25, I48, I71, J15, J80, J96, K65, R07, R57, Z48, Z51

^cFinal model: classical model + I20, I25, I48, J80, R57, Z48, Z51

^dClassical model: age, duration of hospital stay, number of ICD-10 codes, hospital admissions via the emergency department, ICU stay, dialysis, palliative care, Charlson Comorbidity Index

^ePheWAS model: J69, J80, J96, N17, R57, S06

^fFinal model: classical model + J69, J80, R57, S06