. 2017 Nov 22;17:782. doi: 10.1186/s12885-017-3713-7

Table 3.

Interaction between ADH1B rs17033, rs4147536, ALDH2 rs671 polymorphisms, smoking, alcohol consumption and BMI in gastric cancer patients

	Exposure	Status	Genotypes	Control(n-108)	Case (n-105)	OR (95% CI)^a	P value
ADH1B rs17033	Smoking	Non-smoker	AA	64	38	Reference:
		Non-smoker	AG + GG	2	3	3.84 (0.42–35.44)	0.223
		Smoker	AA	32	47	Reference:
		Smoker	AG + GG	5	17	1.25 (0.33–4.67)	0738
	Alcohol	Non-alcoholic	AA	82	57	Reference:
		Non-alcoholic	AG + GG	3	3	1.79 (0.27–11.68)	0542
		Alcoholic	AA	19	28	Reference:
		Alcoholic	AG + GG	4	17	1.63 (0.40–6.60)	0491
	Smoking + Alcohol	Both non-smoker and non-alcoholic	AA	64	35	Reference:
		Both non-smoker and non-alcoholic	AG + GG	2	3	3.84 (0.42–35.44)	0.223
		Both smoker and alcoholic	AA	19	25	Reference:
		Both smoker and alcoholic	AG + GG	4	17	1.63 (0.40–6.60)	0.491
	BMI	<22	AA	23	53	Reference:
	BMI	<22	AG + GG	4	14	1.79 (0.22–14.79)	0.587
ALDH2 rs671	Smoking	Non-smoker	GG	64	40	Reference:
		Non-smoker	GA + AA	2	1	0.28 (0.01–5.83)	0.396
		Smoker	GG	40	48	Reference:
		Smoker	GA + AA	2	16	7.58 (1.34–42.78)	0.009
	Alcohol	Non-alcoholic	GG	82	57	Reference:
		Non-alcoholic	GA + AA	3	3	0.69 (0.08–5.62)	0.725
		Alcoholic	GG	22	33	Reference:
		Alcoholic	GA + AA	1	7	2.15 (0.20–23.50)	0.512
	Smoking +Alcohol	Both non-smoker and non-alcoholic	GG	64	37	Reference:
		Both non-smoker and non-alcoholic	GA + AA	2	1	0.28 (0.01–5.83)	0.396
		Both smoker and alcoholic	GG	22	28	Reference:
		Both smoker and alcoholic	GA + AA	1	14	10.90 (1.16–102.44)	0.010
	BMI	<22	GG	25	56	Reference:
	BMI	<22	GA + AA	2	11	1.38 (0.14–14.01)	0.787
ADH1B rs4147536	Smoking	Non-smoker	GG	36	16	Reference:
		Non-smoker	GT + TT	30	25	1.75 (0.65–4.72)	0262
		Smoker	GG	20	46	Reference:
		Smoker	GT + TT	22	18	0.41 (0.18–0.97)	0.041
	Alcohol	Non-alcoholic	GG	45	33	Reference:
		Non-alcoholic	GT + TT	40	27	0.62 (0.17–2.20)	0.456
		Alcoholic	GG	11	29	Reference:
		Alcoholic	GT + TT	12	16	0.36 (0.08–1.69)	0.188
	Smoking +Alcohol	Both non-smoker and non-alcoholic	GG	36	16	Reference:
		Both non-smoker and non-alcoholic	GT + TT	30	22	1.75 (0.65–4.72)	0.262
		Both smoker and alcoholic	GG	11	29	Reference:
		Both smoker and alcoholic	GT + TT	12	13	0.62 (0.17–2.20)	0.456
	BMI	<22 Kg/m²	GG	17	41	Reference:
	BMI	<22 Kg/m²	GT + TT	10	26	2.81 (0.62–12.62)	0.166

^aOdds ratio were adjusted for age, sex, BMI, alcohol and smoking status, p value < 0.05 is considered to be statistically significant