Table 1.

Inclusion and exclusion criteria

Inclusion criteria

Age 18 and over

Primary degenerative mitral regurgitation (diagnosed and quantified according to the European Association of Echocardiography guidelines)

Exclusion criteria

Secondary mitral regurgitation

Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)

Co-existing moderate or severe aortic valve disease

Congenital heart disease

Inherited or acquired cardiomyopathy

Non-incidental or symptomatic coronary artery disease

Uncontrolled atrial fibrillation (resting heart rate > 100/min)

Pregnancy

Unable to undergo CMR

Unable to undergo cardiopulmonary exercise test