Table 3.
Multivariable-adjusted CVD risk among women with EC compared with cancer-free women in the Women’s Health Initiative, overall and stratified by Type I vs. II, n=93,607
| Variable | CV events/N | CHR (95% CI)1 | p |
|---|---|---|---|
| Overall (Type I and II) | |||
| EC status2 | 0.92 | ||
| No | 15,740/92,217 (17%) | 1.00 | |
| Yes | 212/1,390 (15%) | 1.01 (0.87, 1.16) | |
| BMI | <0.001 | ||
| Normal weight (<25 kg/m2) | 5,139/35,319 (15%) | 1.00 | |
| Overweight (25–29 kg/m2) | 5,387/31,707 (17%) | 1.13 (1.09, 1.18) | |
| Obese (≥30 kg/m2) | 5,277/25,717 (21%) | 1.45 (1.39, 1.51) | |
| Hypertension history | <0.001 | ||
| Never hypertensive | 8,449/62,112 (14%) | 1.00 | |
| Untreated hypertensive | 1,460/6,761 (22%) | 1.58 (1.50, 1.68) | |
| Treated hypertensive | 5,140/19,832 (26%) | 1.86 (1.80, 1.93) | |
| Type I | |||
| EC status2 | <0.001 | ||
| No | 15,740/92,217 (17%) | 1.00 | |
| Yes | 186/1,179 (16%) | 0.98 (0.84, 1.14) | |
| BMI | <0.001 | ||
| Normal weight (<25 kg/m2) | 5,129/35,250 (15%) | 1.00 | |
| Overweight (25–29 kg/m2) | 5,377/31,644 (17%) | 1.13 (1.09, 1.18) | |
| Obese (≥30 kg/m2) | 5,271/25,640 (21%) | 1.46 (1.40, 1.52) | |
| Hypertension history | <0.001 | ||
| Never hypertensive | 8,432/6,1974 (14%) | 1.00 | |
| Untreated hypertensive | 1,460/6,747 (22%) | 1.59 (1.50, 1.68) | |
| Treated hypertensive | 5,133/19,784 (26%) | 1.87 (1.80, 1.93) | |
| Type II | |||
| EC status2 | |||
| No | 15,740/92,217 (17%) | 1.00 | 0.17 |
| Yes | 26/211 (12%) | 1.32 (0.88, 1.97) | |
| BMI | <0.001 | ||
| Normal weight (<25 kg/m2) | 5,096/34,946 (15%) | 1.00 | |
| Overweight (25–29 kg/m2) | 5,344/31,390 (17%) | 1.13 (1.09, 1.18) | |
| Obese (≥30 kg/m2) | 5,180/25,238 (21%) | 1.46 (1.40, 1.52) | |
| Hypertension history | <0.001 | ||
| Never hypertensive | 8,355/61,357 (14%) | 1.00 | |
| Untreated hypertensive | 14,49/6,678 (22%) | 1.59 (1.50, 1.68) | |
| Treated hypertensive | 5,075/19,560 (26%) | 1.87 (1.80, 1.94) | |
| History of cancer (non-endometrial) | 0.31 | ||
| No | 14,562/85,644 (17%) | 1.00 | |
| Yes | 1,051/6,035 (17%) | 1.03 (0.97, 1.10) | |
1
Cox proportional hazards regression models with baseline hazards stratified by trial membership (OS, E+P, DM, E+P and DM) and age as the underlying time scale with adjustment for variables shown
2
EC status was treated as a time-varying covariate
CHR: Cause-specific hazard ratio