. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Pediatr Nephrol. 2017 Aug 4;33(1):139–146. doi: 10.1007/s00467-017-3763-8

Table 3.

Blood pressure response

	eGFR ≥90 mL/min/1.73m² (n=1388)	eGFR <90 mL/min/1.73m² (n=315)	P	eGFR ≥90 mL/min/1.73m² (n=1388)	eGFR <90 mL/min/1.73m² (n=315)	P
	Change in diastolic blood pressure, mmHg			Relative change in diastolic blood pressure, %
Placebo	−3.4 (−17.0, 10.3)	−1.4 (−17.8, 19.7)	0.03	−3.7 (−20.2, 15.9)	−0.7 (−20.8, 29.5)	0.01
Low dose	−3.5 (−18.3, 10.0)	−5.9 (−27.3, 11.0)	0.05	−4.0 (−21.2, 14.7)	−6.4 (−28.6, 14.3)	0.12
Medium dose	−5.1 (−20.3, 7.0)	−5.6 (−26.3, 16.0)	0.68	−6.3 (−24.1, 10.7)	−5.9 (−30.2, 27.4)	0.81
High dose	−6.3 (−23.5, 10.0)	−16.1 (−30.0, −1.3)	<0.001	−7.3 (−26.5, 12.5)	−18.4 (−34.6, −1.9)	<0.001
	Change in systolic blood pressure, mmHg			Relative change in systolic blood pressure, %
Placebo	−5.8 (−23.7, 10.7)	−3.6 (−24.0, 21.0)	0.05	−4.2 (−16.9, 7.6)	−2.6 (−16.4, 17.0)	0.05
Low dose	−6.3 (−24.0, 11.3)	−8.8 (−32.0, 9.7)	0.09	−4.6 (−17.2, 8.9)	−6.6 (−25.3, 8.4)	0.06
Medium dose	−8.2 (−25.0, 6.7)	−8.4 (−31.0, 11.0)	0.88	−5.9 (−18.6, 5.4)	−6.4 (−24.0, 9.2)	0.68
High dose	−10.4 (−28.3, 6.7)	−13.8 (−35.5, 0.0)	0.05	−7.7 (−21.2, 5.7)	−10.7 (−24.1, 0.0)	0.02

Values are presented as mean (5, 95 percentiles).

eGFR indicates estimated glomerular filtration rate.