Table 2.
Proteomics and metabolomics models* in first trimester prediction of term preeclampsia.
| Model | Predictors | AUC (95% CI) | Sensitivity % (95% CI) | Specificity % (95% CI) |
|---|---|---|---|---|
| Maternal factors | Parity, MAP (12 wks), BMI (12 wks) | 0.565 (0.442–0.688) | 62.9% (62.9–78.9) | 50.8% (38.4–63.1) |
| Metabolites | Putrescine, Urea, Carnitine | 0.701 (0.589–0.814) | 72.7% (72.7–87.9) | 57.4% (44.2–70.6) |
| Peptides | TNF-α, RPL41, ATP5E, TBP | 0.694 (0.578–0.811) | 66.7% (66.7–82.8) | 74.1% (62.4–85.8) |
| Metabolites + peptides | TNF-α, RPL41, ATP5E, TBP, Putrescine, Urea, Carnitine | 0.745 (0.638–0.852) | 78.8% (78.8–92.7) | 64.8% (52.1–77.6) |
TBP: TATA box binding protein - associated factor; RPL41: 60S ribosomal protein L41; TNF-α: Tumor necrosis factor alpha (fragment); ATP5E: ATP synthase subunit epsilon; MAP: Mean arterial pressure; BMI: Body mass index.
*Based on logistic regression analysis, threshold values are presented in the supplementary information (Supplementary Table S6).