Table 4.
Proteomics and metabolomics models* in serial integrated (first and third trimester) prediction of term preeclampsia.
| Model | Predictors | AUC (95% CI) | Sensitivity % (95% CI) | Specificity % (95% CI) |
|---|---|---|---|---|
| Maternal factors | MAP (32 wks), MAP (12 wks), BMI (12 wks), BMI (32 wks), | 0.582 (0.460–0.705) | 48.6% (48.6–65.1) | 71.4 (60.3–82.6) |
| Peptides (top model) | TEX15 (3rd tr), TBP (1st tr) | 0.987 (0.961–1.000) | 100% (100–100) | 98.4% (95.3–100) |
| Peptides (2nd model) | GTPBP3 (3rd tr), RPL41 (1st tr) | 0.983 (0.953–1.000) | 97.1% (97.1–100) | 98.4% (95.3-100) |
| Peptides + demographics | GTPBP3 (3rd tr), SCG10 (3rd tr), ATP5E (1st tr), BMI32 wks, MAP32 wks, MAP12 wks | 0.977 (0.949–1.000) | 97.1% (97.1–100) | 90.5% (83.2–97.7) |
| Metabolites | Urea (1st), SM C18:1 (1st), Citrate (3rd), Hexose (3rd), | 0.817 (0.732–0.902) | 81.6% (81.6–93.9) | 71.0% (60.3–81.7) |
| Metabolites + demographics | Urea (1st), Hexose (3rd), SM C18:1 (1st), Citrate (3rd), MAP(32 wks), BMI (12 wks) | 0.805 (0.717–0.894) | 84.2% (84.2–95.8) | 71.0% (60.3–81.7) |
TEX15: Testis-expressed sequence 15 protein; TBP: TATA box binding protein - associated factor; GTPBP3: GTP binding protein 3; RPL41: 60S ribosomal protein L41; SCG10: Stathmin 3; ATP5E: ATP synthase subunit epsilon; MAP: Mean arterial pressure; BMI: Body mass index.
*Based on logistic regression analysis, threshold values are presented in the supplementary information (Supplementary Table S6).