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. 2017 Nov 23;7:16134. doi: 10.1038/s41598-017-16012-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quinalizarin reduces the CK2 kinase activity in lung cancer cells. (A) The chemical structure of Quinalizarin. (B) A549 or H460 cells were treated with DMSO or 25 μM Quinalizarin for 6 or 24 h. The CK2 kinase activity after inhibition was measured by the kinase assay. Proteins were extracted and the CK2 activity was determined using the incorporation of 32P-phosphate into the synthetic substrate RRRDDDSDDD. The cells treated with the solvent DMSO alone were used as a control and the activity was set to 100%. (***p < 0.001) The mean ± S.D. was calculated for three independent experiments. (C) The protein expression of CK2α,α’ and β was measured by Western blot. The mean ± S.D. was calculated for three independent experiments.