Table 4.
Genotype and allele frequencies of SLCO1B1 (T521C) when participants were co-exposed to AFB1 and MC-LR in cases and controls.
| Toxin Exposure | SNP | Cases n(%) | Controls n(%) | OR (95%CI) | P-valuea,b |
|---|---|---|---|---|---|
| ALML | TT | 80 (72.1) | 78 (60.5) | ref | |
| TC/CC | 31 (27.9) | 51 (39.5) | 0.593 (0.344–1.022) | 0.039 | |
| T | 90 (40.5) | 86 (33.3) | ref | ||
| C | 132 (59.5) | 172 (66.7) | 0.733 (0.505–1.064) | 0.062 | |
| ALMH | TT | 78 (69.0) | 69 (64.5) | ref | |
| TC/CC | 35 (31.0) | 38 (35.5) | 0.815 (0.465–1.429) | 0.280 | |
| T | 86 (38.1) | 87 (37.5) | ref | ||
| C | 140 (61.9) | 145 (62.5) | 0.977 (0.669–1.425) | 0.490 | |
| AHML | TT | 60 (52.6) | 82 (75.9) | ref | |
| TC/CC | 54 (47.4) | 26 (24.1) | 2.838 (1.598–5.041) | 0.000 | |
| T | 65 (28.5) | 82 (39.4) | ref | ||
| C | 163 (71.5) | 126 (60.6) | 1.632 (1.094–2.435) | 0.011 | |
| AHMH | TT | 65 (59.6) | 89 (77.4) | ref | |
| TC/CC | 44 (40.4) | 26 (22.6) | 2.317 (1.296–4.142) | 0.003 | |
| T | 77 (35.3) | 104 (45.2) | ref | ||
| C | 141 (64.7) | 126 (54.8) | 1.511 (1.033–2.211) | 0.021 |
Note: aComparing Cases with Control. bFrom chi-square test.
AM meant combined exposure to AFB1 and Microcystin-LR. ALML was defined as those with AFB1 lower than median and with MC-LR lower than median, and so on.