Table 5.
Genotype and allele frequencies of GSTP1 (A1578G) when participants were exposed to AFB1 or MC-LR in cases and controls.
| Toxin Exposure | SNP | Cases n(%) | Controls n(%) | OR (95%CI) | P-valuea,b |
|---|---|---|---|---|---|
| AFB1(L) | AA | 169 (75.4) | 172 (73.2) | ref | |
| AG/GG | 55 (24.6) | 63 (26.8) | 0.889 (0.584–1.351) | 0.328 | |
| A | 344 (76.8) | 352 (74.9) | ref | ||
| G | 104 (23.2) | 118 (25.1) | 0.902 (0.666–1.221) | 0.277 | |
| AFB1(H) | AA | 136 (61.0) | 161 (59.4) | ref | |
| AG/GG | 87 (39.0) | 110 (40.6) | 0.936 (0.652–1.345) | 0.396 | |
| A | 285 (63.9) | 333 (61.4) | ref | ||
| G | 161 (36.1) | 209 (38.6) | 0.900 (0.694–1.167) | 0.233 | |
| MC-LR(L) | AA | 150 (66.7) | 162 (56.8) | ref | |
| AG/GG | 75 (33.3) | 123 (43.2) | 0.659 (0.458–0.947) | 0.015 | |
| A | 308 (68.4) | 335 (58.8) | ref | ||
| G | 142 (31.6) | 235 (41.2) | 0.657 (0.507–0.852) | 0.001 | |
| MC-LR(H) | AA | 155 (69.8) | 171 (77.4) | ref | |
| AG/GG | 67 (30.2) | 50 (22.6) | 1.478 (0.966–2.263) | 0.045 | |
| A | 321 (72.3) | 350 (79.2) | ref | ||
| G | 123 (27.7) | 92 (20.8) | 1.458 (1.069–1.987) | 0.010 |
Note: aComparing Cases with Control. bFrom chi-square test.
L stood for low exposure, and H stood for high exposure.