Table 6.
Genotype and allele frequencies of GSTP1 (A1578G) when participants were co-exposed to AFB1 and MC-LR in cases and controls.
| Toxin Exposure | SNP | Cases n(%) | Controls n(%) | OR (95%CI) | P-valuea,b |
|---|---|---|---|---|---|
| ALML | AA | 83 (74.8) | 87 (68.0) | ref | |
| AG/GG | 28 (25.2) | 41 (32.0) | 0.716 (0.406–1.262) | 0.155 | |
| A | 167 (75.2) | 178 (69.5) | ref | ||
| G | 55 (24.8) | 78 (30.5) | 0.752 (0.501–1.126) | 0.100 | |
| ALMH | AA | 86 (76.1) | 85 (79.4) | ref | |
| AG/GG | 27 (23.9) | 22 (20.6) | 1.213 (0.641–2.295) | 0.333 | |
| A | 177 (78.3) | 174 (81.3) | ref | ||
| G | 49 (21.7) | 40 (18.7) | 1.204 (0.755–1.921) | 0.254 | |
| AHML | AA | 67 (58.8) | 75 (47.8) | ref | |
| AG/GG | 47 (41.2) | 82 (52.2) | 0.642 (0.394–1.044) | 0.048 | |
| A | 141 (61.8) | 157 (50.0) | ref | ||
| G | 87 (38.2) | 157 (50.0) | 0.617 (0.436–0.873) | 0.004 | |
| AHMH | AA | 69 (63.3) | 86 (75.4) | ref | |
| AG/GG | 40 (36.7) | 28 (24.6) | 1.781 (0.999–3.172) | 0.034 | |
| A | 144 (66.1) | 176 (77.2) | ref | ||
| G | 74 (33.9) | 52 (22.8) | 1.739 (1.146–2.641) | 0.006 |
Note: aComparing Cases with Control. bFrom chi-square test.
AM means combined exposure to AFB1 and Microcystin-LR. ALML was defined as those with AFB1 lower than median and with MC-LR lower than median, and so on.