Figure 14.

The scheme of driver patterns identification. (1) Acquire the initial gene modules for gene expression profiles via WGCNA network analysis (on the left) and extract a pool of candidate modulators as initial driver genes integrate CNVs and Somatic mutations in ovarian cancer samples (on the right); (2) Construct the heterogeneous network by module networks learning and evaluate the regulatory relationships by liner regression model; (3) Identify modulators interactions in the constructed regulatory networks and analyze the driver patterns through and gene ontology analysis and pathway enrichment analysis.