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. 2017 Nov 23;7:16153. doi: 10.1038/s41598-017-16543-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic analysis of the subcutaneous inguinal adipose tissue of postnatal Egr1 ^−/− versus Egr1 ^+/+ mice reveals downregulation of extracellular matrix genes. (A) List of downregulated extracellular matrix genes in 6 inguinal subcutaneous fat pads of 3 Egr1 ^−/− versus 3 Egr1 ^+/+ 2-week-old mice. (B,C) RT-qPCR analysis of gene expression levels for extracellular matrix genes, Col1a1, Col5a2, Col14a1, Fn1, Postn, Dcn and Mmp2, in SC-WAT of 2-week-old (B) and 4-month-old (C) Egr1 ^+/+ and Egr1 ^−/− mice. For each gene, the mRNA levels of control (Egr1 ^+/+) SC-WAT were normalized to 1. Graphs show means ± standard deviations of 5 samples from 2-week-old Egr1 ^+/+ mice and Egr1 ^−/− mice, 6 samples from 4-month-old Egr1 ^+/+ mice and 5 samples from Egr1 ^−/− mice. The relative mRNA levels were calculated using the 2^−ΔΔCt method. The p-values were obtained using the Mann-Withney test. Asterisks indicate the p-values *p < 0.05, **p < 0.01.