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. 2017 Nov 23;7:16153. doi: 10.1038/s41598-017-16543-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EGR1 regulates beige adipocytes differentiation, metabolism and extracellular matrix formation. Egr1 loss-of-function upregulates the expression of genes encoding C/EBPß, PGC1α, UCP1, COX8B, SUCLA2, OGDH, CIDEA, PLIN5, PANK1 and DIO2, leading to a significant browning of SC-WAT in Egr1 ^−/− mice. Egr1 deletion downregulates the expression of genes encoding the ECM proteins Collagens, Fibronectin and Perisotin. Our study confirms the opposite correlation between adipose tissue browning and fibrogenesis.