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. 2017 Nov 23;7:16159. doi: 10.1038/s41598-017-16327-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signaling pathway variation between PC3 and PC3M cells. Reverse-phase protein array (RPPA) analysis was used to identify differences in expression of various proteins in PC3 and PC3M cells (n = 3 samples per cell type). The x-axis labels represent selected proteins targeted by the antibodies used in the analysis; V is validated and C is course. The validated antibodies have been shown in multiple assays to target only the protein named and not to have off-target binding; course antibodies have off-target binding. PC3M cell lysates expressed higher levels of phosphorylated AKT (Akt-pS473, P < 0.01, unpaired t-test using Holm-Sidak method for multiple comparisons), 4E-BP1, and mTOR than PC3 cell lysates. Expression of AMPK and p-AMPK was higher in PC3 cell lysates.