Figure 3.

Intralipid treatment reduces the toxic side effects of Abraxane. (A) Changes of the body weight of rats upon administration of Abraxane, with and without treatment of Intralipid (N = 4). (B–I) Light microscopic images of the spleen tissue sections treated with Abraxane, with or without Intralipid. (J–M) are from the spleen-tissue sections of the naïve SD rats. Spleen tissue sections were stained with H&E (B,C,F,G and J,K) and TUNEL (D,E,H,I, and L,M). In (D,E,H,I and M), red arrows indicate the apoptotic cells. (B–E) are observed from the spleen-tissue sections of the Abraxane administrated, but no Intralipid-treated, animals. (F–I) are from the Intralipid-treated animals. (N–Y) Light microscopic images of the H&E-stained (N,O,R,S, and V,W) and the TUNEL-stained (P,Q,T,U, and X,Y) kidney tissue sections. The red arrows on (Q,U and Y) indicate the apoptotic cells. (Q) Shows an enlarged view of the apoptotic kidney cells.