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. 2017 Nov 23;8:1738. doi: 10.1038/s41467-017-01460-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Expression of immune related genes and association to benefit from ACT in melanoma. a Enrichment plots from gene set enrichment analysis for the immune system and cell cycle pathways. b MHC class I expression score was constructed from indicated genes. c Progression-free and overall survival by MHC score quartile. P-values from Cox regression. d Expression of immune response related and melanoma lineage genes in patients with no clinical benefit (green) and with clinical benefit (orange). Signatures in the lower left panel (T and B cells, Macrophages, Endothelial cells, and CAF) are derived from publication by Tirosh et al.²⁸. Star denotes genes with significant association to benefit from ACT (P < 0.05, t-test)