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. 2017 Nov 23;7:16115. doi: 10.1038/s41598-017-16394-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cells expressing wild type p53 show reduced sensitivity to inhibitors, GSK461364 and BI6727. (A,B,E) Parental HCT116 (p53+/+) cells and a derivative line lacking p53 expression (p53−/−) were treated for 72 h with increasing concentrations of the PLK1 inhibitors, GSK461364 (A) or BI6727 (B), or with taxol (E). Cell viability was then measured using an MTS assay. (C,D,F) HCT116-p53+/+ or -p53−/− cells treated for 72 h with increasing concentrations of GSK461364 (C), BI6727 (D) or taxol (F). Following removal of drugs, cells were grown for a further 12 days. Surviving colonies were detected by staining with crystal violet. Data are representative of three independent experiments each conducted in duplicate.