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. 2017 Nov 23;7:16115. doi: 10.1038/s41598-017-16394-2

Figure 2.

Figure 2

Cells expressing wild type p53 show a partial G1 arrest in response to GSK461364 or BI6727. HCT116-p53+/+ or -p53−/− cells were treated for 24 h with GSK461364 (20 nM) or BI6727 (10 nM) or with DMSO as control. Cells were subsequently harvested and analyzed by flow cytometry. Arrows highlight increased number of p53+/+ cells in G1 following drug treatment as compared with the p53−/− cells. The data are representative of two independent experiments, each done in triplicate. Error bars represent the standard deviation of the mean.