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. 2017 Nov 23;7:16151. doi: 10.1038/s41598-017-16275-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteomic analysis of Mfrp ^rd6 /Mfrp ^rd6 and AAV2/8-mMfrp RPE reveal differentially-expressed proteins. (A) Hierarchal clustering of proteins differentially-expressed in Mfrp ^rd6 /Mfrp ^rd6 and AAV2/8-mMfrp mice compared to B6 controls. Results are represented as a heatmap and display protein levels on a logarithmic scale. A total of 137 proteins were differentially-expressed among the 3 groups (p < 0.05). (B) Pathogenic features of nanophthalmos. Illustration provided by Lucy Evans (acknowledgements section). (C) Correlations between pathogenic features of high hyperopia and the molecular pathways identified in our proteomic analysis.