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. 2017 Jul 31;36(46):6383–6390. doi: 10.1038/onc.2017.256

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Flow chart of informative loci identification and marker validation. This work can be divided into two phases: the computational identification of informative MST loci phase and the marker validation phase. Phase 1: 488 non-small cell lung germline cancer samples from the TCGA and 390 germline non-cancer control samples from the 1000 genomes project we analyzed. This analysis yielded 119 MST loci that have significant genotype difference in the cancer and control samples. Phase 2: this set of 119 markers, along with 144 MST markers that were computationally found to be significant for others cancers, were pooled into a target enrichment kit which was used to sequence at high depth a total of 30 lung cancer samples and 89 non-cancer control samples. Of these 263 (119+144) MST markers, 21 were found to consistently differentiate lung cancer and control samples.