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. 2017 Jul 31;36(46):6383–6390. doi: 10.1038/onc.2017.256

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The computationally harvested LUAD and LUSC MST loci differentiate their corresponding cancer type from 1000 genomes non-cancer control samples with high sensitivity (LUAD: 0.87, LUSC: 0.88). (a) A sample with 39% (vertical black line; identified via ROC analysis) or more of the 96 LUAD specific MST loci with cancer genotype will be called ‘at-risk’ for adenocarcinoma of the lung. (b) A sample with 37% or more of the 67 LUSC specific MST loci with cancer genotype will be called ‘at-risk’ for squamous cell carcinoma. Blue bars represent control samples and orange bars represent lung cancer germline samples.